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Mini-Dictionary

Acetylcholine: Chemical which acts as a neurotransmitter. An imbalance between dopamine and acetylcholine results in some Parkinson's disease symptoms.

Dopamine: Neurotransmitter or "chemical messenger" that controls movement. It is deficient in the brains of Parkinson's disease patients. Taken orally, it cannot cross the blood-brain barrier and produces side effects such as nausea.

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Some history...

Parkinson's disease was first described in 1817 by Dr. James Parkinson. His "Essay on the Shaking Palsy" was so detailed that his description of the characteristic tremor and slowness of movement are still used nowadays as a basis for diagnosis.

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   Parkinson's Disease

Parkinson's disease (PD) is a slow progressive neurological disorder of the central nervous system, which affects more than one million Americans.

The gradual degeneration of the affected brain cells causes a reduction of a vital chemical known as "dopamine", essential to control muscle activity. Patients with Parrkinson's disease show tremor on one side of the body when at rest, slow movements, and problems with walking and keeping their balance.

At a later stage, Parkinson's patients develop dementia and eventually Alzheimer's disease.

Medication include levodopa, which converts itself into dopamine once inside the brain, and deprenyl, which prevents degeneration of the dopamine-containing neurons. They can reduce somewhat the symptoms that Parkinson's patients experience, but they can't correct the underlying mental changes that occur.

 
In the news...
SEPTEMBER 1998

tb.gif (76 bytes) Disruptions in ubiquitin protein linked to Alzheimer's and Parkinson's disease  (9/19)


Associations
National Parkinson Foundation, Inc.
1501 NW 9th Avenue, Miami, FL 33136
305-547-6666
800-327-4545

The Parkinson's Disease Foundation
710 West 168th St., New York, NY 10032
212-923-4700
800-457-6676

Parkinson's Support Group of America
11376 Cherry Hill Road, #204
Beltsville, MD 20705
301-937-1545

Internet Links
tb.gif (76 bytes) National Parkinson Foundation Inc.

tb.gif (76 bytes) The Parkinson's Web

tb.gif (76 bytes) Parkinson's Information

tb.gif (76 bytes) The American Parkinson's Disease Association

 

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